Reviews have described the conducting of Matilda Hofman as "taut and finely controlled", "unerring", and as giving "a striking sense of purpose". She has a varied and busy conducting schedule in California and Europe. In Europe, Matilda has performed at the Salzburg Festival, Berliner Festspiele, Holland Festival, Ruhrtriennale, Luzern Festival, Paris Autumn Festival, and at the Guggenheim in Bilbao. She has worked with Ensemble Modern, Ensemble Recherche, SWR Sinfonie-orchester, Bochumer Symponiker and Kammerakademie Potsdam.

Matilda is Music Director of the Diablo Symphony Orchestra and conductor for the Empyrean Ensemble, as well as being a member of the Left Coast Chamber Ensemble. Matilda has guest conducted for many orchestras in California, including the San Francisco Ballet, and serves as cover conductor for projects with the San Francisco Symphony. In 2019 and 2021 Matilda was a resident artist at Oberlin Conservatory of Music.

Matilda also enjoys working with choirs, which have included Volti in San Francisco and Chorwerk Ruhr in Germany whom she prepared for their successful debut with the Berlin Philharmonic in MusikFest Berlin, with George Benjamin conducting.

She has been responsible for the commission of new works from her student days on, including works by Cheryl Frances-Hoad, Deborah Pritchard, Aida Shirazi and Eun Young Lee.

Matilda's website is